How to Break Out of Fight-or-Flight with CBG, CBN, and Vagus Nerve Resets

What causes chronic fight-or-flight mode?

Chronic stress can trap the body in fight-or-flight mode, keeping the sympathetic nervous system overactive while the parasympathetic system is underutilized. This imbalance suppresses digestion, spikes cortisol, disrupts sleep, and keeps the body primed for perceived danger long after the threat is gone.

How can CBG help calm anxiety and improve gut health?

CBG (Cannabigerol) interacts with serotonin (5-HT1A) receptors and reduces gut inflammation via CB₂ receptor activity—helping shift the nervous system back toward a parasympathetic state.

• A double-blind, placebo-controlled trial found 20 mg CBG significantly lowered anxiety without sedation (PubMed).

• Preclinical studies show CBG supports gut motility and reduces oxidative stress (PMC).

Recommended: 100 mg CBG sublingually in the morning and midday to maintain calm, support digestion, and help pull the body out of fight-or-flight.

Does CBN really help you sleep better?

CBN (Cannabinol) may improve sleep continuity and reduce nighttime awakenings, which can be disrupted when the nervous system is stuck in fight-or-flight mode.

• A 2024 RCT found 20 mg CBN reduced night waking without grogginess (PubMed).

• Higher doses (100 mg) may enhance these effects, especially when combined with a calm, parasympathetic bedtime routine.

What is a vagus nerve reset?

A vagus nerve reset stimulates the parasympathetic nervous system (“rest-and-digest”) to counteract the overdrive of fight-or-flight.

Top vagus nerve exercises:

• Breathing: 5.5 sec inhale, 5.5 sec exhale for 5–10 min

• Humming/Chanting: Stimulates vagal tone via vocal cords

• Cold Face Immersion: Splash cold water or finish showers cold

• Ear Massage: Targets auricular vagus branches

• Gargling: Engages vagal motor fibers

What is the daily cannabinoid and vagus nerve protocol?

Morning – 100 mg CBG + breathing and humming to start the day in a parasympathetic state
Midday – 100 mg CBG + quick vagus stimulation (ear massage, gargle, cold splash) to prevent a stress spike
Evening – 100 mg CBN 45–60 min before bed + slow breathing for deeper sleep
During panic – 25–50 mg rapid-acting CBG to help halt a fight-or-flight surge

Can gut health improve with this approach?

Yes. Calming the nervous system and restoring parasympathetic dominance helps digestion resume normally. Adding chamomile tea, slippery elm, aloe vera juice, and probiotic foods supports gut lining repair and microbiome balance—closing the loop between gut health, anxiety, and sleep quality.

Bottom line

Combining CBG for daytime calm, CBN for sleep, and vagus nerve stimulation offers a science-backed way to escape chronic fight-or-flight. By restoring parasympathetic function, supporting gut health, and improving sleep, you give your body the tools it needs to reset—naturally and effectively.