Tremors, Tension & Relief: The Role of Cannabinoids in Parkinson’s Care

Living with Parkinson’s presents daily challenges that can be frustrating, exhausting, and sometimes disheartening. From tremors and muscle stiffness to sleep disturbances and pain, managing symptoms can feel overwhelming. However, emerging research suggests that cannabinoids like CBG, CBN, and full-spectrum extracts may offer relief and improve quality of life.

CBG: The “Mother of All Cannabinoids”

Cannabigerol (CBG) is often called the "mother" of cannabinoids because other cannabinoids (like CBD and THC) start as CBG before evolving into their final forms. But what can it do for Parkinson’s?

• Neuroprotection: CBG may shield neurons from damage and inflammation, potentially slowing down neurodegeneration. One study found that CBG helped preserve dopamine-producing cells in mice with Parkinson’s-like conditions (MDPI Study).

• Dyskinesia Reduction: Research shows CBG, especially when paired with CBD, may help reduce L-DOPA-induced dyskinesia—those involuntary movements caused by long-term Parkinson’s medication. Some studies indicate cannabinoids can start showing effects on dyskinesia within days to weeks of consistent use (CBGA Crumble). Another study on CBD’s role in managing dyskinesia found that improvements were observed in as little as two weeks (PubMed Study).

CBN: A Natural Ally for Sleep and Neuroprotection

CBN (cannabinol) is best known for promoting relaxation and sleep, but research suggests it may also have neuroprotective benefits.

• Cellular Protection: The Salk Institute found that CBN protects brain cells from oxidative stress, a major factor in neurodegenerative diseases like Parkinson’s (Salk Institute Study).

• Better Sleep, Less Stress: Sleep disturbances are common in Parkinson’s, and CBN’s natural sedative properties may help improve sleep quality and reduce stress-related symptom exacerbation.

Full-Spectrum CBD: Supporting Holistic Wellness

Full-spectrum CBD, which includes small amounts of various cannabinoids, terpenes, and flavonoids, works synergistically to enhance potential benefits. Here’s what the research suggests for Parkinson’s:

• Symptom Management: A review of clinical studies found cannabinoids improved both motor and non-motor symptoms, with CBD showing benefits for pain relief, sleep, and mood stability (PubMed Study).

• Quality of Life Boost: A small study showed that Parkinson’s patients who took 300 mg/day of CBD reported a significant improvement in overall well-being compared to a placebo group (PubMed Study).

• Brain Protection: Preclinical research suggests CBD interacts with key receptors to reduce neuroinflammation and protect brain cells (PubMed Study).

Topical Cannabinoids: A Gentle Approach to Physical Relief

Cannabinoid lotions and balms are not a cure, but they can provide targeted comfort for some of the physical symptoms associated with Parkinson’s.

• Muscle Stiffness & Cramping: High-potency full-spectrum lotions infused with CBG, CBN, and menthol (like our bestselling 5500mg menthol lotion) may help relax tight muscles and provide relief from discomfort.

• Tremor Management: While topicals won’t directly reduce tremors, some people report that applying CBD or CBG-infused creams to their hands or legs helps ease muscle tension, allowing for smoother movements.

• Nerve Pain & Sensitivity: Many people with Parkinson’s experience neuropathy-like symptoms. Cannabinoid topicals may help by interacting with CB2 receptors in the skin to ease pain and inflammation.

Exploring Options for Comfort and Support

If you’re considering cannabinoids as part of your Parkinson’s management plan, the growing body of research suggests they may offer benefits. While more studies are needed, early findings are promising, and many people report positive experiences. If you’re interested, talk to your doctor about whether cannabinoids could be a helpful addition to your care routine.

Have you or a loved one tried cannabinoids for Parkinson’s symptoms? Share your experiences in the comments below—we’d love to hear from you.