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Emerging peer-reviewed research suggests that non-psychoactive cannabidiol (CBD) may do more than reduce inflammation—it may influence molecular pathways involved in intestinal fibrosis and gut health. Recent studies highlight CBD’s interaction with key signaling systems such as Nrf2 and TGF-β/SMAD, offering new insight into how cannabinoids may support gut resilience without intoxication. This science-forward review breaks down what the latest research actually shows.