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Emerging research shows that cannabinoids like CBG, CBN, and full-spectrum CBD can help manage multiple sclerosis (MS) by calming neuroinflammation, easing spasticity, improving sleep, and supporting neuroprotection. Peer-reviewed studies highlight CBG’s ability to regulate immune signaling and reduce microglial overactivation, while full-spectrum CBD—often paired with THC—has been clinically shown to reduce MS-related pain, stiffness, bladder dysfunction, and fatigue. CBN may further improve quality of life by enhancing GABA activity and supporting muscle relaxation during sleep. When paired with holistic therapies like medicinal mushrooms, yoga, cold exposure, and anti-inflammatory nutrition, this layered approach offers a powerful, science-backed protocol for symptom relief and long-term nervous system support in MS.