Supporting Pediatric Glioblastoma Naturally: Cannabinoids and Holistic Therapies That Show Promise

A Natural Path Through a Tough Diagnosis

A glioblastoma diagnosis is overwhelming, especially when it affects a child. These aggressive brain tumors are difficult to treat, and while chemotherapy and radiation are standard, many families are seeking integrative solutions that support the body without adding toxicity. At Beyond Wellness, we explore options that blend plant-based science, holistic care, and peer-reviewed research. Here’s everything you should know about using cannabinoids like THC, CBG, CBN, and full-spectrum CBD, alongside holistic strategies for pediatric glioblastoma (GBM) management.

Cannabinoids and Their Anti-Tumor Promise

Research is showing that cannabinoids may do more than just manage symptoms. In preclinical studies, these plant compounds actually slowed tumor growth, triggered cancer cell death, and reduced inflammation. Some even showed the ability to target glioma stem cells, which are thought to drive recurrence.

• THC has been found to trigger cell death in glioblastoma cells, reduce inflammation, and ease pain, appetite loss, and nausea.

• CBD works without the psychoactive effects and is known for calming inflammation, modulating immune function, and improving quality of life. It also appears to enhance the effect of other therapies.

• CBG is a rising star for its ability to target glioma stem cells and suppress tumor invasion. When paired with CBD, their anti-cancer effects were even stronger.

• CBN, typically known for sleep support, has also been shown to reduce glioma cell proliferation in early lab studies.

Importantly, these cannabinoids appear to work better together than in isolation — this is known as the "entourage effect." A full-spectrum oil or balanced formula may be more effective than a single isolate.

Real-Life Inspiration: Integrative Cases

One case report shared how a patient with glioblastoma refused chemotherapy and instead followed a holistic protocol using THC/CBD cannabis, high-dose melatonin, and ozone therapy. The result? A durable remission and high quality of life. Another case combined CBD oil with traditional therapies and saw enhanced tumor shrinkage.

Clinical trials in adults using balanced THC:CBD extracts (like Sativex) showed improved survival and quality of life when added to traditional care. While pediatric studies are limited, these adult trials and case reports help guide safe, compassionate use in teens under medical supervision.

Beyond Cannabinoids: A Holistic Cancer Support Plan

At Beyond Wellness, we believe cannabinoids are just one piece of a much larger wellness puzzle. Here are the top holistic tools families can consider adding to a pediatric cancer support plan:

• Ketogenic Diet: Glioblastoma cells feed on glucose. A supervised keto or low-sugar, anti-inflammatory diet may help “starve” tumors while supporting healthy cells.

• Boswellia Serrata (Frankincense): Reduces brain swelling and may assist with inflammation-driven symptoms.

• Curcumin (Turmeric Extract): Targets multiple tumor pathways and enhances the effect of other treatments.

• Reishi & Turkey Tail Mushrooms: Immune-modulating mushrooms that support the body’s ability to fight cancer.

• Omega-3 Fatty Acids: Help reduce inflammation and support brain health.

• Mindfulness & Breathwork: Reduces stress hormones, improves immune response, and fosters mental resilience.

• Gentle Movement: Chair yoga, qigong, or adapted exercises support strength and reduce fatigue.

Topical & Internal Wellness with Beyond Wellness Products

For families integrating cannabinoids, we recommend:

• 5500 mg Menthol Lotion: Our best-selling full-spectrum topical with 3500 mg CBD, 

• 1000 mg CBN, and 1000 mg CBG for nerve pain, muscle relief, and inflammation.

• Full-Spectrum CBD & CBG Tinctures: Clean, lab-tested, and formulated for therapeutic use.

• CBN Sleep Drops: For restorative rest and recovery.

Always consult a healthcare provider experienced in cannabinoid therapy, especially when working with children. Pediatric dosing must be cautious, monitored, and tailored to the child’s body and biology.

Hope Through Harmony

Cancer care should never be one-size-fits-all. Families navigating glioblastoma deserve more than just survival strategies — they deserve pathways to thrive. At Beyond Wellness, we are here to support you with products, research, and education that align with your values.

To explore our full cannabinoid wellness line or to consult on building a holistic care plan, visit thebeyondwellnessstore.com or come into our El Dorado Hills store.

You are not alone. Let’s walk this path together.

Sources:

• Feng S. et al. “From bench to bedside: the application of cannabidiol in glioma.” J Transl Med. 2024 – (Review of CBD in glioma: apoptosis, autophagy, and sensitization of tumors to therapy)
  
  

• Lah TT. et al. “Cannabigerol is a potential therapeutic agent in a novel combined therapy for glioblastoma.” Cells. 2021 – (CBG and CBD synergistically induced apoptosis and inhibited GBM cell invasion, targeting stem-like cells)
  
  

• Zhong N. et al. “Cannabinol inhibits cell growth and triggers cell cycle arrest and apoptosis in cancer cells.” Biocatal Agric Biotech. 2023 – (CBN reduced proliferation of A172 glioma cells, modulated cannabinoid receptors and inhibited ERK, causing G1/S cell cycle arrest)
  
  

• Twelves C. et al. “A phase 1b randomised, placebo-controlled trial of nabiximols cannabinoid spray with temozolomide in recurrent GBM.” British J Cancer. 2021 – (THC:CBD spray was safe; 1-year survival 83% vs 44% for add-on cannabinoid vs placebo, prompting further trials)
  
  

• Schloss P. et al. (conference data) – described in Curr Treat Options Oncol. 2022 – (88-patient study of cannabis oil in high-grade glioma showed good tolerability, improved sleep and quality of life in users)
  
  

• Guzmán M. et al. “A pilot clinical study of Δ⁹-THC in patients with recurrent GBM.” British J Cancer. 2006 – (Intratumoral THC in 9 patients was feasible and safe; median survival ~6 months, with indication that THC did not hasten tumor growth in CB receptor-positive tumors)
  
  

• Dall’Stella P. et al. “Case report: Two patients with high-grade glioma treated with chemoradiation, PCV, and cannabidiol.” Front Oncol. 2019 – (Unusual tumor responses seen with addition of CBD; suggests CBD might improve chemoradiation efficacy)
  
  

• Antonini M. et al. “Medical Cannabis, Melatonin, and Oxygen–Ozone Therapy in GBM: A Case Report.” Curr Oncol. 2023 – (GBM patient refusing standard therapy achieved long-term complete remission with this unconventional integrative regimen)
  
  

• Lissoni P. et al. “Radioneuroendocrine strategy with radiotherapy plus melatonin vs radiotherapy alone in GBM.” Oncology. 1996 – (1-year survival 6/14 vs 1/16 in favor of melatonin; melatonin group had lower RT/steroid side effects and better quality of life)
  
  

• Kirste S. et al. “Boswellia serrata acts on cerebral edema in irradiated brain tumor patients: placebo-controlled trial.” Cancer. 2011 – (Boswellia 4.2 g/day led to >75% edema reduction on MRI in 60% of patients vs 26% placebo; no severe side effects)
  
  

• Alvarez Pinzón A. et al. “Role of the Ketogenic Diet in managing glioblastoma.” Cancer Neurosci (MDPI). 2024 – (Review suggests KD is safe in brain tumor patients and possibly associated with improved survival; calls for more research on anti-tumor efficacy)
  
  

• Torres S. et al. 2011 (preclinical): demonstrated THC + temozolomide strongly synergized in killing GBM cells, including TMZ-resistant lines, by enhancing autophagy. Also showed adding CBD to THC+TMZ further increased anti-tumor effects.
  
  

• Current Treatment Options in Oncology, 2022 (Bora-Singhal et al.) – “Therapeutic and Supportive Effects of Cannabinoids in Brain Tumors” – (Summarizes that cannabinoids inhibit cancer cell proliferation, migration, angiogenesis and induce apoptosis; whole-plant extracts work synergistically, and cannabinoids have a favorable safety profile in brain tumor patients, helping with pain, nausea, appetite, etc.).